研究業績

研究業績

 

1) 論文
 
1. Aptamers that bind specifically to human KPNA2 (importin-α1) and efficiently interfere with nuclear transport. Noriko Yasuhara, Penmetcha Kumar. Journal of Biochemistry, in press (2016)
 
2. Transcriptional program of Kpna2/Importin-α2 regulates cellular differentiation-coupled circadian clock development in mammalian cells. Yasuhiro Umemura, Nobuya Koike, Tsuguhiro Matsumoto, Seung-Hee Yoo, Zheng Chen, Noriko Yasuhara, Joseph S. Takahashid, and Kazuhiro Yagita. PNAS. 111, 5039-48(2014)
 
3. Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin β. Choi Saehae. Yamashita Eiki, Yasuhara Noriko, Song Jinsue, Son Se‐Young, Won Young Han, Hong Hye Rim, Shin Yoon Sik, Sekimoto Toshihiro, Park Il Yeong, Yoneda Yoshihiro, Lee Soo Jae. Acta Crystallographica Section D. 70:1050-60 (2014)
 
4. Importin alpha subtypes determine differential transcription factor localization in embryonic stem cells maintenance. Noriko Yasuhara, Ryosuke Yamagish, Yoshiyuki Arai, Rashid Mehmood, Chihiro Kimoto, Toshiharu Fujita, Kenichi Touma, Azumi Kaneko, Yasunao Kamikawa, Tetsuji Moriyama, Toshio Yanagida, Hiroki Kaneko, Yoshihiro Yoneda. Developmental Cell. 26, 123-35 (2013)
 
5. Improvement in protocol to generate homogeneous glutamatergic neurons from mouse embryonic stem cells reduced apoptosis. Ryosuke Fujiki, Akinobu Sato, Katsuhiko Hata, Fumi Tashiro, Noriko Yasuhara, Jun-ichi Miyazaki, Yoshihiro Yoneda, Masashi Fujitani, Toshihide Yamashita. Biochemical and Biophysical Research Communications. 432, 604-609 (2013)
 
6. Cross-talk between distinct nuclear import pathways enables efficient nuclear import of E47 in conjunction with its partner transcription factors. Rashid Mehmood, Noriko Yasuhara, Masahiro Fukumoto, Souichi Oe, Taro Tachibana, Yoshihiro Yoneda.  Molecular Biology of the Cell 19, 3715-3724 (2011)
 
7. Cell type-specific transcriptional regulation of the gene encoding importin-α1. Yasunao Kamikawa , Noriko Yasuhara, Yoshihiro Yoneda. Experimental Cell Research  317, 1970-1978 (2011)
 
8. Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on importin β. Ryo Oharaa, Katsuhiko Hata, Noriko Yasuhara, Rashid Mehmood, Yoshihiro Yoneda, Masanori Nakagawa, Toshihide Yamashita. Biochemical and Biophysical Research Communications  405, 697-702 (2011)
 
9. Molecular basis for the recognition of phosphorylated STAT1 by importin α5. Jonathan Nardozzi, Nikola Wenta, Noriko Yasuahra, Uwe Vinkemeier, Gino Cingolani. Journal of Molecular Biology 402, 83-100 (2010)
 
10. Synergestic nuclear import of NeuroD1 and its partner transcription factor, E47, via heterodimerization. Rashid Mehmood, Noriko Yasuhara, Souichi Oe, Masahiro Nagai, Yoshihiro Yoneda. Experimental Cell Research 315, 1639-52 (2009)
 
11. Triggering neural differentiation of ES cells by subtype switching of importin-α. Noriko Yasuhara, Noriko Shibazaki, Shinya Tanaka, Masahiro Nagai, Yasunao Kamikawa, Souichi Oe, Munehiro Asally, Yusuke Kamachi, Hisato Kondoh, & Yoshihiro Yoneda. Nature Cell Biology, 9, 72-79, (2007).
 
12. Importin α/β-mediated nuclear protein import is regulated in a cell cycle-dependent Manner. Noriko Yasuhara, Eri Takeda, Hitomi Inoue, Ippei Kotera, Yoshihiro Yoneda.  Experimental Cell Research 297, 285-293, (2004)
 
13. Identification of Ewing’s Sarcoma gene product as a glycoprotein using a monoclonal anti-body that recognizes an immunodeterminant containing O-Linced N-Acetylglucosamine Mioety. Yousuke Matsuoka, Yuriko Matsuoka, Satoshi shibata, Noriko Yasuhara, Yoshihiro Yoneda. Hybridoma and Hybridomics 21, 233-236, (2002)
 
14. Programmed cell death triggered by insect steroid hormone, 20-hydroxyecdysone,in the anterior silk gland of the silkworm, Bombix mori. Jun Terashima, Noriko Yasuhara, Masafumi Iwami, Sho Sakurai. Development Genes and Evolution 210, 545-558, (2000)
 
15. Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell deathLee Jeong-Hwa, Takashi Takahashi, Noriko Yasuhara, Joji Inazawa, Shinji Kamada, Yoshihide Tsujimoto. Oncogene, 18, 6183-6190, (1999)
 
16. Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated inspinal muscular atrophy. Hiromi Iwahashi, Yutaka Eguchi, Noriko Yasuhara, Toshiaki Hanafusa, Yuji Matsuzawa, Yoshihide Tsujimoto. Nature 390, 413-417, (1997)
 
17. A functional role for death proteases in s-Myc- and c-Myc-mediated apoptosis. Shigehide Kagaya, Chifumi Kitanaka, Kohji Noguchi, Toshihiro Mochizuki, Akinori Sugiyama, Akiko Asai, Noriko Yasuhara, Yutaka Eguchi, Yoshihide Tsujimoto, Yoshiyuki Kuchino. Molecular Cell Biology 11, 6736-6745, (1997)
 
18. Evidence against a functional site for Bcl-2 downstream of caspase cascade in preventing apoptosis. Noriko Yasuhara, Setuko Sahara, Shinnji Kamada, Yutaka Eguchi, Yoshihide Tsujimoto, Oncogene 15, 1921-1928, (1997)
 
19. Essential Role of Active Nuclear Transport in Apoptosis. Noriko Yasuhara, Yutaka Eguchi, Taro Tachibana, Naoko Imamoto, Yoshihiro Yoneda, Yoshihide Tsujimoto, Genes to Cells, 2, 55-64, (1997)
 
2) 総説
 
1. 核―細胞質間分子輸送による細胞の高次機能制御 上川泰直、安原徳子、米田悦 実験医学 8月号 Vol.28 No.13 (2010)
 
2. The role of the nuclear transport system in cell differentiation Noriko Yasuhara, Masahiro Oka, Yoshihiro Yoneda*, (invited review) 
Seminars in Cell and Developmental Biology 5, 590-599 (2009)
 
3. 細胞分化と核―細胞質間分子輸送システム 安原徳子、岡正啓、米田悦啓*
最新医学 64巻3月増刊号 78-87 (2009)
 
4. 核―細胞質間蛋白質輸送と高次生命現象 安原徳子、米田悦啓*
生体の科学 Vol.59, No.5 348-349 (2008)
 
5. 細胞分化を制御する核輸送受容体 importinα 安原徳子 米田悦啓
蛋白質核酸酵素 5月号 427-433 (2007)